In the limit n→∞: Var(λ^)∼λ2/n. Asymptotically the MLE saturates the Cramér-Rao bound. But the CRB applies only to unbiased estimators; since λ^ is biased, the bound is only meaningful asymptotically.
Mean close to 0, variance close to λ2=4. The n(λ^−λ) distribution is approximately N(0,λ2), saturating the Cramér-Rao lower bound asymptotically.
Takeaways
Fisher information is the reciprocal of the asymptotic variance. Large I(θ) means data is very informative about θ; small I means poor.
MLE is asymptotically efficient: it achieves the CRB asymptotically. No unbiased estimator can do asymptotically better.
Finite-sample bias doesn't matter asymptotically but matters for small n. For exponential rate, the bias decays as 1/(n−1), which is small for n≥50.
The formula SE(θ^)=1/nI(θ^) is the workhorse approximation. It gives quick, approximate confidence intervals: θ^±1.96⋅SE(θ^).
Connection to OLS. OLS is MLE under gaussian errors; the Fisher-information matrix for β is X⊤X/σ2, giving Var(β^)=σ2(X⊤X)−1 — exactly the OLS covariance formula derived earlier.